Doctor Who Fandom Curse: Knowing that at some point your Doctor will have to regenerate.

Supernatural Fandom Curse: Knowing that your Series will end.... and soon.

Avengers Fandom Curse: Knowing that Joss Whedon will likely kill a favorite character.

Twilight Fandom Curse: Knowing that you will never win a fight against another fandom.... ever.

Harry Potter Fandom Curse: Knowing that it will never be as good as the first time around.

Sherlock Fandom Curse: Knowing that after waiting forever you will probably only get three more episodes with a cliff hanger even worse than the previous one.

Queer as Folk Fandom Curse: Knowing that it's only time...and there won't be another episode to repair the damage done by the finale.

Glee Fandom Curse: The show

American Horror Story Fandom Curse: Knowing that Tate Langdon no longer exists after the first season.

Community Fandom Curse: Knowing that your show is on hiatus. Indefinitely.

Chuck Fandom Curse: ... It ended.